2025’s Top 5 Vitamin B12 Supplements – A Buyer’s Guide
Choosing the right vitamin B12 supplement for your everyday health and wellness can be overwhelming, but it is important to focus on these three key points: Natural ingredients, effectiveness, and value for money.
Wondering why you should even worry about supplementing with B12? Vitamin B12 is a water-soluble vitamin that is essential for many bodily functions, including energy production, DNA synthesis, blood cell formation, and nerve health. Your body needs vitamin B12 to function properly. As we age, our bodies become less efficient at absorbing vitamin B12 from food, so it is important to get enough from other sources—like supplements![4]
Vitamin B12 is crucial for good health, especially as you age or if you follow a strict vegan or vegetarian diet. But most vitamin B12 supplements are expensive and don't deliver on their promises. That's why we're excited to discover the brand ‘Pattern Wellness’, a company that's making waves with their high-quality Vitamin B12 Liquid Drops at a fraction of the cost.
Interested, but feeling lost? We’ve got you covered.
There are many different vitamin B12 supplements on the market, so it is important to choose one that is as effective as it is high quality. Look for a supplement that is made with natural ingredients, such as methylcobalamin in sublingual liquid form. Methylcobalamin has been shown to be the most bioavailable and holistic coenzyme form of vitamin B12. This means that the body can absorb the B12 more easily and effectively than other forms, like cyanocobalamin or powdered capsules and tablets.[5]
Finally—you’ll want a superior quality vitamin B12 supplement that is made with naturally sourced ingredients for maximum results. Find a B12 supplement that only has the essentials without the unnecessary ingredients. There are high-quality supplements out there that are free of gluten, dairy, and soy and are non-GMO and vegan-friendly.
It can be difficult to know which are the best vitamin B12 supplements on the market. We’re here to help. We’ll show you what to look for and what to avoid when picking vitamin B12 supplements, and how they can help transform your health and well-being.
Benefits of B12
Promotes Red Blood Cell Formation[6]
- Bolsters Iron Absorption & Fights Back Against Anemia
- Decreases Oxidative Stress at a Cellular Level
Boosts Energy & Metabolic Function [7,8]
- Helps Decrease Fatigue & Increase Energy Capacity
- Converts Carbohydrates, Fats, & Proteins into Glucose
Hair, Skin, & Nail Support[1,2,3]
- Promotes Collagen Synthesis for Stronger Skin
- Ensures Adequate Oxygen & Nutrient Delivery for Optimal Function
Comprehensive Nutrition for Overall Health[9,10,11]
- Helps to Balance Healthy Immune Responses
- Maintains Efficient Cognitive & Nerve Functions
What You Need In The Perfect Vitamin B12 Supplement
Taking all of the healthful attributes listed above into consideration, we've boiled down a list of four key characteristics you should always look for in quality vitamin B12. Try to seek out all of these qualities:
Pure Ingredients
Supplements should give you only what you need and nothing that you don’t. Look for supplements that have pure, simple ingredients—the less on the label, the better. It ensures you are getting all the benefits that vitamin B12 has to offer.
In terms of the type of vitamin B12, look for Methylcobalamin in the form of sublingual liquid on the label, which is the most highly biochemically active form of B12. Another great addition to vitamin B12 supplements is natural flavors so the supplement is not only easy to take, but enjoyable and delicious as well.[5]
Naturally Sourced & Allergen-Free
A lot of supplements on the market can contain common allergens and genetically modified ingredients that aren’t all that healthy for you. Find a vitamin B12 supplement that is naturally sourced and has quality ingredients that are certified vegan, non-GMO, and free of gluten, dairy, and soy.
Effective Dosage & Practices
In the world of supplements, the dosage is important. The recommended daily allowance for vitamin B12 is based on the potencies used in clinical studies. Higher doses have been found to be safe and effective, as your body absorbs only as much as it needs and any excess passes through your urine. Be on the lookout for vitamin B12 supplements that offers you maximum strength daily dosing so you can experience optimal benefits.12]
Additionally, look for vitamin B12 supplements that are Good Manufacturing Practice (GMP) Certified. This means that the product met strict manufacturing quality standards and was adequately tested and dosed for optimal effectiveness.
100% Satisfaction Guarantee
Ensure that the product you buy has an explicit satisfaction guarantee on all purchases. This proves the company is confident in its products and its priority is to give customers peace of mind when buying their products.
What To Avoid When Buying Vitamin B12 Supplements
Unnecessary Additives
Labels on supplements are sometimes created to be deceiving or confusing to the consumer. This is because many supplements come with binders, fillers, preservatives, potential allergens, and other unnecessary additives like food coloring. These additives provide no medical benefit and disregarding them may potentially cause allergic reactions or sensitivity.
When it comes to choosing your vitamin B12 supplement, be picky. Check the ingredients and don’t settle for less than healthy.
Sacrificing Quality for Price
Selecting the cheapest rather than the best quality can potentially do you more harm than good. If brands don’t identify certain ingredients or nutrients and their amounts in each dose, you could end up with an ineffective or potentially harmful supplement.
TOP 5 Vitamin B12 supplements of 2025
Based on our extensive research, the metrics provided by our ranking system, and consideration of thousands of reviews by shoppers just like you, we've compiled a list of what we've found to be the top five products in this category, on the market today.
1. Vitamin B12
Total Ranking
1130 votes
9.7/10
A+
Overall GradePROS
- Supports Heart Health, Immunity, & Overall Health
- Simplistic Formula
- Natural Orange Citrus Flavor
- Uses a Potent, Highly Absorbable Form of B12
- Offers a Max Strength of 5,000 mcg
- Certified Vegan & Non-GMO
- Dairy-, Gluten, & Soy-Free
- Money-Back Guarantee
- No Fillers or Binders
- Excellent US-Based Customer Service
CONS
- Only Available Online
The Bottom Line
Look no further than Pattern Wellness' Liquid B12 for the best vitamin B12 supplement on the market today—-effective, delicious, and easy to use are just a few of its many pros.
This science-backed formula is made with high-quality, plant-based ingredients, including the highly absorbent and bioavailable form of B12—Methylcobalamin. It's also conveniently flavored with a delightful natural orange citrus flavor.
But what really sets Pattern Wellness' Liquid B12 apart is its commitment to quality. The company rigorously 3rd Party Lab Tests their products for efficacy and purity, so you can be sure you're getting the best possible product.
And if you're not happy with your purchase, Pattern Wellness offers a 90-day, risk-free, money-back guarantee.
*Results are based on the PatternLiving Ranking System and do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.
Learn About Our Top Pick2. Vitamin B12 5,000 mcg Sublingual Liquid
Total Ranking
742 votes
9.1/10
A-
Overall GradePROS
- Affordable
- High Potency with 5,000 mcg
- Available in a Liquid Form
- No Artificial Colors, Flavors, or Preservatives
- Money-Back Guarantee
CONS
- Contains Sugar Alcohol
- Unpleasant Flavorings
- Uses Cyanocobalamin Form of B12
- Reported Side Effects
The Bottom Line
Nature's Bounty is a well-known brand that offers a wide variety of B12 supplements. Their sublingual liquid B12 is a convenient and affordable way to get your daily dose of this essential vitamin, as all you have to do is simply place a few drops under your tongue and let it dissolve.
However, this supplement is not without its drawbacks. Some customers have reported side effects such as nausea and diarrhea. Additionally, the formula contains sugar alcohol, which may not be suitable for everyone. Some customers have also found the flavoring to be too sweet and needed to dilute it with water to improve the taste.
*Results are based on the PatternLiving Ranking System and do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.
Learn More3. B12 Vitamin Spray
Total Ranking
627 votes
8.7/10
B+
Overall GradePROS
- Sublingual Methylcobalamin
- Gluten-Free & Non-GMO
- Vegetarian/Vegan
- No Artificial Colors or Flavors
- Satisfaction Guarantee
- 3rd Party Tested
CONS
- Uses a Spray Bottle Design
- Includes Stevia Leaf Extract
- Reports of Bitter Flavoring
- Reports of Possible Side Effects
The Bottom Line
Salt Lake Supplements' B12 Vitamin Spray is a decent product, but it has some sour notes. The spray bottle makes it difficult to control the dosage, and the cherry flavoring is more bitter than sweet. Some consumers have also reported side effects like acid reflux, diarrhea, and irritability.
On the plus side, this supplement is easy to absorb as it is bioactive sublingual Methylcobalamin, and free of harmful additives. And if you're not satisfied, you can return it with a full satisfaction guarantee.
*Results are based on the PatternLiving Ranking System and do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.
Learn More4. Fully Active B12
Total Ranking
476 votes
8.1/10
B-
Overall GradePROS
- Highly Absorbable Form of B12
- Simplified, Stripped-Back Formula
- Vegetarian, Vegan, & Soy-Free
- Money-Back Guarantee
CONS
- Difficult to Swallow Capsules
- Reports of Poor Quality Assurance
- Not Sublingual
- Slow to See Results
The Bottom Line
Doctor's Best Fully Active B12 is a vegan supplement that's packed with vitamin B12, but it's not without its faults. On the plus side, the supplement includes Methylcobalamin, the most bioavailable form of B12, in a potent daily dose of 1500 mcg. It's also free of GMOs, gluten, and soy, so you can have peace of mind while taking it.
But the downside? It's not sublingual or liquid, so it's not absorbed as efficiently and you don’t get the most bang for your buck. Plus, there have been some quality control issues reported by consumers, which could mean inaccurate dosages or contamination.
*Results are based on the PatternLiving Ranking System and do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.
Learn More5. Vitamin B-6 B-12 Folic Acid DropIns
Total Ranking
226 votes
7.9/10
C+
Overall GradePROS
- Includes B6 & Folate
- Formulated for High Absorption
- Manufactured in a GMP Certified Facility
- 60-Day Money-Back Guarantee
CONS
- Includes Xylitol & Stevia Leaf Extract
- Reports of Degradation
- Reports of Excessive Sweetness
- Needs to Be Refrigerated
The Bottom Line
KAL’s Vitamin B-6 B-12 Folic Acid DropIns include a hearty source of B6, B12, and folic acid, which are important vitamins for energy production, brain health, and red blood cell production. These drops are manufactured in a GMP-certified facility and lab-verified, so you can be sure of their quality. They also come with a 60-day money-back guarantee.
Unfortunately, that’s where the pros come to an end. This formula includes xylitol and stevia leaf, two sweeteners known to cause stomach upset or allergic reactions in some people, especially in those sensitive to certain dietary restrictors.[13] Additionally, consumers have reported the degradation of the liquid over time, which calls into question the integrity of this supplement’s packaging. Not to mention this particular B12 vitamin supplement requires refrigeration after opening which could be seen as an inconvenience.
*Results are based on the PatternLiving Ranking System and do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.
Learn MoreFinal Thoughts
The Bottom Line
When it comes to choosing the right vitamin B12, it is essential to choose a product that is made with high-quality ingredients delivered in optimal doses from a brand you can trust.
After searching the internet to find the best vitamin B12 supplement and evaluating them based on their customer service, ingredients, and pricing, we believe Pattern Wellness’ B12 is the best on the market.
Pattern Wellness provides a 100% satisfaction guarantee or your money back.
Take advantage of this Offer while supplies last - Use code below:
Sources
- DiBaise, M., & Tarleton, S. M. (2019). Hair, Nails, and Skin: Differentiating Cutaneous Manifestations of Micronutrient Deficiency. Nutrition in clinical practice: official publication of the American Society for Parenteral and Enteral Nutrition, 34(4), 490–503. https://doi.org/10.1002/ncp.10321
- Brescoll, J., & Daveluy, S. (2015). A review of vitamin B12 in dermatology. American journal of clinical dermatology, 16(1), 27–33. https://doi.org/10.1007/s40257-014-0107-3
- V. HANUMANTHA RAO AND S. M. BOSE. (1970). Effect of vitamin B12 on the Formation of Collagen and Nucleic Acids in the Albino Rat Skins and Granulomas. stage. https://www.jstage.jst.go.jp/article/jnsv1954/16/4/16_4_253/_pdf
- O'Leary F, Samman S. vitamin B12 in health and disease. Nutrients. 2010 Mar;2(3):299-316. doi: 10.3390/nu2030299. Epub 2010 Mar 5. PMID: 22254022; PMCID: PMC3257642. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257642/
- Institute of Medicine (US) Standing Committee on the Scientific Evaluation of Dietary Reference Intakes and its Panel on Folate, Other B Vitamins, and Choline. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington (DC): National Academies Press (US); 1998. 9, vitamin B12. Available from: https://www.ncbi.nlm.nih.gov/books/NBK114302/
- Ankar A, Kumar A. vitamin B12 Deficiency. [Updated 2022 Oct 22]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK441923/
- vitamin B12 (cobalamin). Mount Sinai Health System. (n.d.). Retrieved February 15, 2023, from https://www.mountsinai.org/health-library/supplement/vitamin-b12-cobalamin
- Ling, C. T., & Chow, B. F. (1954). The influence of vitamin B12 on carbohydrate and lipide metabolism. Journal of Biological Chemistry, 206(2), 797–805. https://doi.org/10.1016/s0021-9258(19)50851-1
- Batista, K. S., Cintra, V. M., Lucena, P. A. F., Manhães-de-Castro, R., Toscano, A. E., Costa, L. P., Queiroz, M. E. B. S., de Andrade, S. M., Guzman-Quevedo, O., & Aquino, J. S. (2022). The role of vitamin B12 in viral infections: a comprehensive review of its relationship with the muscle-gut-brain axis and implications for SARS-CoV-2 infection. Nutrition Reviews, 80(3), 561–578. https://doi.org/10.1093/nutrit/nuab092
- Gröber, U., Kisters, K., & Schmidt, J. (2013). Neuroenhancement with vitamin B12-underestimated neurological significance. Nutrients, 5(12), 5031–5045. https://doi.org/10.3390/nu5125031
- Calderón-Ospina, C. A., & Nava-Mesa, M. O. (2020). B Vitamins in the nervous system: Current knowledge of the biochemical modes of action and synergies of thiamine, pyridoxine, and cobalamin. CNS neuroscience & therapeutics, 26(1), 5–13. https://doi.org/10.1111/cns.13207
- U.S. Department of Health and Human Services. (2023). Office of dietary supplements - vitamin B12. NIH Office of Dietary Supplements. https://ods.od.nih.gov/factsheets/VitaminB12-HealthProfessional/
- Ruiz-Ojeda FJ, Plaza-Díaz J, Sáez-Lara MJ, Gil A. Effects of Sweeteners on the Gut Microbiota: A Review of Experimental Studies and Clinical Trials. Adv Nutr. 2019 Jan 1;10(suppl_1):S31-S48. doi: 10.1093/advances/nmy037. Erratum in: Adv Nutr. 2020 Mar 1;11(2):468. PMID: 30721958; PMCID: PMC6363527. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363527/
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