Top 5 Cholesterol Supplements of 2025 – A Buyer’s Guide
High cholesterol is a silent killer. It can lead to serious health problems like heart disease and stroke, but most people don't even know they have it. In fact, about two in five adults in the U.S. have high cholesterol. [10] You're probably asking yourself 'How do I lower my Cholesterol?', well look no further as we have the answers!
Cholesterol is a waxy, fat-like substance that's essential for life. It's found in every cell in your body and helps to make hormones, vitamin D, and digestive enzymes. Your body makes most of the cholesterol it needs, but you can also get it from food. There are two main types of cholesterol: HDL (the "good" cholesterol) and LDL (the "bad" cholesterol). HDL transports cholesterol away from your arteries and back to your liver, where it's broken down and removed from your system. LDL, on the other hand, can build up in your artery walls and form dangerous plaques.[10,11]
Want to lower your cholesterol? With a few simple dietary changes, regular exercise, and a supportive supplement, you can keep your cholesterol in check and enjoy life to the max.
But cholesterol supplement shoppers, beware! The crowded market is teeming with ineffective and unsafe products that promise to lower cholesterol. Many supplements contain low doses of active ingredients, harmful additives, and misleading labels. Even the efficacy of some of these cholesterol-lowering supplements is questionable.
Luckily, you don't need to sweat the details—we've done the work for you. When choosing a cholesterol complex, look for these three must-haves: natural ingredients, proven results, and an affordable price. That's why we're thrilled to discover Pattern Wellness' Cholesterol Complex, a premium supplement that checks off all our boxes.
For optimal results, choose a high-quality cholesterol complex supplement made with pure, natural ingredients. Avoid products with unnecessary fillers and additives. There are many high-caliber cholesterol supplements available that are gluten-free, dairy-free, soy-free, non-GMO, and vegan-friendly.
Confused about the best cholesterol supplements on the market? We're here to help you navigate the complex choices and find the right supplements to support your everyday health.
Why Do Doctors Recommend Natural Cholesterol Supplements?
Your liver is a cholesterol factory, constantly producing it to build cells and hormones. But too much cholesterol can clog your arteries like a traffic jam, narrowing them and increasing your risk of heart disease.
Statins are prescription medications that lower LDL (“bad”) cholesterol by blocking an enzyme in the liver that helps make it. They can be effective, but they also have side effects.[17]
This raises the question: are statins worth the risk? For doctors, they’re not. More and more doctors are backing natural cholesterol supplements instead of statins. Here’s why:
- Side effects: Natural cholesterol supplements are generally considered to be safe, even for people with sensitive stomachs. Statins can have side effects like muscle pain, headaches, and stomach upset. Some people may not be able to tolerate them.
- Cost: Natural cholesterol supplements are usually less expensive than statins, especially if you are not taking a generic version.
- Preferences: Some people simply prefer to take natural supplements over prescription medications.
Doctors will typically recommend natural cholesterol supplements in addition to diet and exercise before trying a prescription statin.
Benefits of Cholesterol Complex Supplements[1-9]
Blood Flow Boost
- Supports Blood Flow, Which Helps to Keep Circulatory Function Strong
- Helps Promote Softer, More Flexible Blood Vessels, Which May Reduce Heart Risks
Cholesterol-Friendly
- Promotes Healthy Arteries by Reducing LDL Cholesterol
- Supports the Balancing of Healthy HDL Cholesterol Levels
Happy, Healthy Heart
- Protects Against Oxidative Damage & Inflammation—Major Risk Factors for Heart Disease
- Helps to Reduce Strain on Heart & Circulation by Lowering Blood Pressure
Full Body Wellness
- Supports a Boost in Immunity, Which May Help to Fight Off Infection
- Fights Back Against Harmful Free Radicals that Can Cause Cell Damage
What You Need In The Perfect Garlic Supplements
Taking all of the healthful attributes listed above into consideration, we've boiled down a list of four key characteristics you should always look for in a quality cholesterol supplement. Try to seek out all of these qualities:
Science-Backed Potency
How can you lower cholesterol and keep it under control? Choose a cholesterol complex crafted with potent, all-natural ingredients that have been scientifically shown to help promote healthy cholesterol levels and maintain them over time.
The best cholesterol-lowering supplements deliver high levels of key healthful ingredients, such as:
- Phytosterols: Phytosterols are plant compounds that are similar in structure to cholesterol. They can block the absorption of cholesterol from food, which can help to lower LDL cholesterol levels.[8]
- Red yeast rice: Red yeast rice is a fermented rice product that contains compounds that can help to lower LDL cholesterol levels. These compounds are known as monacolins and are similar to the active ingredient in prescription statins.[4]
- Garlic: Garlic contains compounds called allicin and ajoene, which have been shown to help lower LDL cholesterol levels and raise HDL cholesterol levels.[5]
- Niacin (vitamin B3): Niacin helps to lower LDL cholesterol levels by increasing the breakdown of cholesterol in the liver. Niacin also helps to raise HDL cholesterol levels by increasing the production of HDL cholesterol.[12]
Look for a cholesterol supplement that's also packed with plant-based extracts that do more than just support healthy cholesterol. These compounds have been shown in clinical studies to offer a wide range of health benefits, including:
- Bergamot: Lowers LDL cholesterol and raises HDL cholesterol.[13]
- Amla fruit: Reduces inflammation and promotes a happy, healthy heart.[14]
- Pine bark extract: Improves blood flow and circulation.[15]
- Olive leaf extract: Boosts the immune system and helps to fight infection.[16]
All-Natural, Allergy-Friendly
Don't settle for a cholesterol complex that's full of fillers and allergens. Choose a naturally sourced, vegan, non-GMO, gluten-free, dairy-free, and soy-free formula made with high-quality ingredients that are good for your body.
No Surprises: Clear Labeling for Safe Products
Be wary of cholesterol-lowering products with unclear labels. Read the ingredients, dosing, and sourcing information carefully to ensure you're getting only what you need.
Additionally, look for Good Manufacturing Practice (GMP) Certified cholesterol supplements. This means the product meets strict manufacturing quality standards and has been adequately tested and dosed for optimal effectiveness.
Try it, Love it, or Return it
Don't let buyer's remorse ruin your shopping experience. Look for a money-back guarantee, which means you can try a product risk-free and return it for a full refund if you're not satisfied. Just be sure to read the fine print carefully to make sure you understand the terms of the guarantee. For example, some guarantees may only apply to new or unused items, or they may have a time limit.
What To Avoid When Buying Cholesterol Supplements
Unnecessary Additives
Labels on supplements are sometimes created to be deceiving or confusing to the consumer. This is because many supplements come with binders, fillers, preservatives, potential allergens, and other unnecessary additives like food coloring. These additives provide no medical benefit and disregarding them may potentially cause allergic reactions or sensitivity.
When it comes to choosing your cholesterol complex supplement, be picky. Check the ingredients and don’t settle for less than healthy.
Sacrificing Quality for Price
Selecting the cheapest rather than the best quality can potentially do you more harm than good. If brands don’t identify certain ingredients or nutrients and their amounts in each dose, you could end up with an ineffective or potentially harmful supplement.
TOP 5 Cholesterol SUPPLEMENTS OF 2025
Based on our extensive research, the metrics provided by our ranking system, and consideration of thousands of reviews by shoppers just like you, we've compiled a list of what we've found to be the top five products in this category, on the market today.
1. Cholesterol Complex
Total Ranking
975 votes
9.7/10
A+
Overall GradePROS
- Contains 8 Potent Ingredients
- Advanced Plant-Based Formula
- Designed to Boost Heart Health & Circulatory Function*
- Certified Vegan & Non-GMO
- Dairy-, Gluten-, & Soy-Free
- Money-Back Guarantee
- No Fillers or Binders
- Excellent US-Based Customer Service
CONS
- Only Available Online
The Bottom Line
Pattern Wellness offers customers a unique plant-based formula that contains 8 natural (and science-backed) cholesterol-balancing ingredients to boost heart health, circulatory function, and overall wellness. We were thrilled to find that their Cholesterol Complex includes every single key ingredient we love: phytosterols, red yeast rice, garlic, niacin, bergamot, amla fruit, pine bark extract, and olive leaf extract. We were even more thrilled to find that this complex is free of fillers, additives, and preservatives, and sticks to a clean and simple vegan formulation.
What really sets this complex and this company apart is their commitment to customer service. Pattern Wellness offers a 100% satisfaction guarantee, and their customer service team is available 24/7 to answer any questions or concerns.
*Results are based on the PatternLiving Ranking System and do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.
Learn About Our Top Pick2. CholestMD
Total Ranking
742 votes
9.1/10
A-
Overall GradePROS
- Includes Garlic, Olive Leaf, Bergamot, & Niacin
- Backed by Doctors
- Lab-Tested & GMP Certified
- Shellfish-, Peanut-, Dairy-, & Wheat-Free
- Non-GMO
- Money-Back Guarantee
CONS
- Missing Key Ingredients
- Reported Side Effects
The Bottom Line
We love CholestMD by 1MD Nutrition for its simplicity. While sticking to the basics, this formula also still includes beneficial natural ingredients like garlic, olive leaf, bergamot, and niacin for optimal results. Not to mention it’s 3rd-party lab tested, GMP-certified, and comes with a generous money-back guarantee.
Unfortunately, this formula is missing quite a few of our favorite key ingredients—phytosterols, red yeast rice, amla fruit, and pine bark extract—all of which have been clinically proven to boost health and wellness. Additionally, we discovered several reports from customers of possible side effects such as night sweats and flatulence.
*Results are based on the PatternLiving Ranking System and do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.
Learn More3. Cholesterol Heart Health
Total Ranking
644 votes
8.7/10
B+
Overall GradePROS
- Includes Generous Doses of Plant-Based Extracts
- All-Natural & Carefully Selected Ingredients
- Soy-, Gluten-, Dairy-, & GMO-Free
- Lab-Tested & GMP-Certified
- Money-Back Guarantee
CONS
- Contains Fish
- Reports of Low Efficacy
The Bottom Line
UpNourish’s Cholesterol Heart Health supplement checks off a lot of our boxes. Their all-natural formulation is made with cholesterol-lowering powerhouses like niacin, plant sterols, bergamot, olive leaf, and garlic. It is soy-, gluten-, dairy-, and GMO-free, and it is lab-tested and GMP-certified. It’s also risk-free.
Although this product meets quite a bit of our criteria, including many of our favorite science-backed natural ingredients, it gets our third ranking for containing a potential allergen—fish. Additionally, we found that some customers reported limited effectiveness after taking this supplement.
*Results are based on the PatternLiving Ranking System and do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.
Learn More4. Cholesterol Health
Total Ranking
497 votes
8.1/10
B-
Overall GradePROS
- Science-Backed Ingredients
- Includes Raw Whole-Food Proprietary Blend
- Lab-Tested & GMP Certified
- GMO-, Gluten-, Dairy-, Soy-, & Preservative-Free
CONS
- Missing Key Ingredients
- Reports of Poor Taste
- No Money-Back Guarantee
The Bottom Line
The Cholesterol Health supplement by Emerald Laboratories is a science-backed supplement with a whole-food proprietary blend. It contains niacin, red yeast rice, and garlic, which are all excellent ingredients for supporting cholesterol health. Emerald Labs also makes it clear that their product is additive-, filler-, binder-, and preservative-free (which we love).
However, even with the added whole-food proprietary blend (which contains some extra goodies like probiotics and sprout powders), the complex is still missing some of our favorite key ingredients. Additionally, there is no money-back guarantee, so it is important to do your research before purchasing this supplement. Finally, some customers have reported that the capsules have a bitter, distasteful flavor.
*Results are based on the PatternLiving Ranking System and do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.
Learn More5. CholestePure
Total Ranking
247 votes
7.9/10
C+
Overall GradePROS
- Includes a Blend of Phytosterols
- Lab-Tested & GMP-Certified
- GMO-, Filler-, Binder-, Artificial Colors-, & Dairy-Free
- Certified Gluten-Free
- Vegetarian
CONS
- Missing Key Ingredients
- Contains Soy
- 30-Day Return Policy
- Non-Returnable Unless Damaged
The Bottom Line
Pure Encapsulations is a reputable brand with a wide range of doctor-approved products. Their CholestePure phytosterol complex is a good option for people looking for a comprehensive blend of phytosterols. It contains beta-sitosterol, campesterol, and stigmasterol, which are plant compounds that have been shown to lower cholesterol levels.
However, CholestePure also has some drawbacks. It is the most expensive complex on our list and does not have a return policy. This means that it is a risky purchase, as you may be stuck with a product you are not happy with. The complex also contains soy and only contains phytosterols. This means that it may not be as effective as other complexes that contain a wider range of ingredients.
*Results are based on the PatternLiving Ranking System and do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.
Learn MoreFinal Thoughts
The Bottom Line
When choosing a cholesterol complex supplement, look for a product with high-quality ingredients, optimal doses, and a trusted brand.
After evaluating many cholesterol-lowering supplements on factors such as customer service, ingredients, and price, we confidently recommend Pattern Wellness' Cholesterol Complex as the best on the market.
Pattern Wellness' Cholesterol Complex is made with high-quality ingredients, including red yeast rice, niacin, and garlic extract. It also has a 100% satisfaction guarantee, so you can try it risk-free.
Take advantage of this Offer while supplies last - Use code below:
Sources
- https://ods.od.nih.gov/factsheets/Niacin-Consumer/
- https://doi.org/10.1155/2018/9395804
- https://doi.org/10.1016/j.conctc.2019.100499
- https://doi.org/10.3390/antiox9070619
- https://doi.org/10.1002/ptr.6234
- https://doi.org/10.14715/cmb/2017.63.10.7
- https://doi.org/10.5935/abc.20170158
- https://doi.org/10.3390/antiox12081509
- https://doi.org/10.1161/cir.0000000000001074
- https://www.ncbi.nlm.nih.gov/books/NBK513326/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858911/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8469228/
- https://doi.org/10.3390/nutraceuticals3030026
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