Top 5 Gut Health Supplements of 2025 – Don’t Buy Until You Read This!

Top 5 Gut Health Supplements of 2025 – Don’t Buy Until You Read This!

By: Rachel

People often try popular diets in an effort to solve their digestive problems, but these diets often fail to address the root cause of these issues - poor gut health. As a result, they do not effectively improve digestive health.

Many modern foods don't contain the essential nutrients required for maintaining a healthy gut balance. Research has shown that the gut has a significant impact on various aspects of our health, including digestion, lung function, heart health, and even brain function. When the number of harmful bacteria in the gut outweighs the beneficial bacteria, it can have negative effects on our overall health.

Scientific research suggests that you can treat and even prevent some illnesses with supplements containing certain kinds of live bacteria. High-quality probiotics & prebiotics contain those live and active microorganisms needed to achieve immune and digestive health benefits.[3] 

Given the benefits of probiotics & prebiotics for overall health, it's not surprising that many people are using them. However, it is important to be cautious when choosing a probiotic product, as not all of them are created equal. With a wide variety of options available, it can be difficult to determine which probiotics are truly effective.

That's why Pattern Living has compiled months of research about this emerging category. We’ll show you what to look for and what to avoid when picking gut support supplements, and how it can help transform your health and wellbeing.

Benefits of Probiotics

Maintains Digestive Balance[1,5]

  • Improves Gut Health Issues
  • Balances Gut Flora

Improves Immune Health[2,4]

  • Reduces Levels Of Harmful Gut Bacteria
  • Boosts Immune Function

Gut-Brain Axis[9]

  • Help Boost Mood & Cognitive Function
  • Lower Stress & Anxiety

What You Need In The Perfect Probiotics

Taking all of the healthful attributes listed above into consideration, we've boiled down a list of four key characteristics you should always look for in quality probiotics. Try to seek out all of these qualities:

High Count of CFU’s (Colony Forming Unit)

CFU refers to the amount of live and active micro-organisms found in each serving. The micro-organisms will begin to colonize the good bacteria in your digestive tract, hence the name. The amount of CFU’s can play a role in how effective the probiotic is.[6] 

While millions sound like a lot, you want a probiotic that has a dose that contains organisms in the billions. To achieve optimum immune and digestive health benefits that probiotics can provide, make sure you have the correct amount of a proven strain.

Probiotics

Probiotics are live “good” bacteria that provide numerous health benefits.[6] There are two probiotics in particular that are worth noting:

Lactobacillus is a type of probiotic enzyme that has been shown to regulate the epithelial barriers in your body.[11] One very important epithelial barrier is the one that lines the digestive tract. By keeping this intact, you’ll have much lower chances of developing leaky gut syndrome.

Another probiotic strain, Bifidobacteria is amazing for colon health—especially for maintaining the colonic lining and preventing colitis.[12] On top of that, it helps to protect the intestinal barrier, likely providing therapeutic benefits for those who suffer from a leaky gut.

Prebiotics

Prebiotics are a form of dietary fiber. They feed the “good” bacteria in your gut and ultimately support a healthier digestive system.[13]

Look for a prebiotic blend that includes Organic Inulin, FOS, and Organic Apple Pectin. Inulin and FOS are longer chain and shorter chain fibers that help the good gut bacteria stay fed and flourish, while Apple Pectin helps inhibit the growth of harmful bacteria and provides extra fiber to assist with digestive health.[14,15,16]  

Abiotic™ Blend

An Abiotic Blend aids in the digestion of macronutrients. This blend includes Allicin (from organic garlic), Monolaurin (from Palm kernels), and NAC. Allicin specifically can provide a gut boost and detox to revive uncomfortable stomachs and balance healthy gut bacteria.[17,18]

What To Avoid When Buying Probiotic Supplements

Unnecessary Additives

Labels on supplements are sometimes created with the intention of being deceiving or confusing to the consumer. This is due to the fact that many supplements come with fillers, preservatives, potential allergens, and other unnecessary additives like sugars or food coloring. These additives provide no medical benefit and disregarding them may potentially cause allergic reactions or sensitivity. 

When it comes to choosing your probiotics, be picky. Check the ingredients and don’t settle for less than healthy.

Sacrificing Quality for Price

Selecting the cheapest rather than the best quality can potentially do you more harm than good. If brands don’t identify specific strains and their amounts in each dose, you could end up with an ineffective or potentially harmful supplement. 
Additionally, an effective probiotic depends on the survival of the micro-organisms. They are delicate and must survive numerous obstacles before they reach you, like manufacturing and packaging. If the micro-organisms start to deplete during that process, the supplement is going to be less effective.[8] Therefore, you need to choose a high-quality probiotic that can survive that process.

TOP 5 GUT HEALTH SUPPLEMENTS OF 2025

Based on our extensive research, the metrics provided by our Pattern Living Ranking System, and consideration of thousands of reviews by Shoppers just like you, we've compiled a list of what we've found to be the top five products in this category, on the market today.

1. Gut Support

by Pattern Wellness

Ranked #1
Gut Support

Total Ranking

1012 votes

9.7/10

A+

Overall Grade
  • INGREDIENT QUALITY
    9.7 AVG.
     9.7/10
  • POTENCY & ESTIMATED EFFICACY
    9.7 AVG.
     9.7/10
  • Value
    9.6 AVG.
     9.6/10
  • Return Policy
    9.6 AVG.
     9.6/10
  • CUSTOMER SATISFACTION
    9.5 AVG.
     9.5/10

PROS

  • Supports Healthy Gut Function
  • Promotes Healthy Gut Bacteria
  • Contains Prebiotics, Probiotics, & Abiotic™ Blend
  • No Fillers or Binders
  • Certified Vegan & Non-GMO
  • Gluten, Dairy, & Soy-Free
  • Excellent US-based customer service

CONS

  • Only Available Online
The Bottom Line

Pattern Wellness’ Gut Support offers an incredible value featuring a blend of Probiotics and prebiotics, and an Abiotic blend, which are packed with many healthful benefits including digestive and immune support, promoting healthy gut bacteria, and reduces the effects of seasonal allergies.*

This certified hormone-free, non-GMO supplement is free of gluten, dairy, and soy, making it a formula you can trust. 

Their return policy includes a 90-day, risk-free, money-back guarantee—proving the company stands behind its products.

*Results are based on the PatternLiving Ranking System and do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.

Learn About Our Top Pick

2. Probiotic with Prebiotic Fiber Blend

by Physician’s CHOICE

Ranked #2
Probiotic with Prebiotic Fiber Blend

Total Ranking

742 votes

9.1/10

A-

Overall Grade
  • INGREDIENT QUALITY
    9.2 AVG.
     9.2/10
  • POTENCY & ESTIMATED EFFICACY
    9.4 AVG.
     9.4/10
  • Value
    8.9 AVG.
     8.9/10
  • Return Policy
    9 AVG.
     9/10
  • CUSTOMER SATISFACTION
    9.5 AVG.
     9.5/10

PROS

  • 60 Billion CFUs
  • 10 Strains
  • Delayed-Release
  • Contains Organic Prebiotic
  • Designed for Survivability

CONS

  • Delayed Results
  • Possible Stomach Issues
  • 30-Day Return Policy
The Bottom Line

The next probiotic to make the list is Physician’s CHOICE, which features an Organic Prebiotic Fiber Blend to aid with digestive and immune support. Containing 60 billion CFUs and 10 strains, this probiotic is designed for survivability thanks to the Patented Shelf-Stable bottle, ensuring high-quality results until the expiration date.

However, there are a few cons to consider. Despite the high amount of CFUs and strains, some reviewers have stated they experienced delayed results, so it may take more than one 30-day container to experience the results. Additionally, those with super sensitive stomachs did experience some side effects, such as diarrhea, bloating, and stomach pain.

*Results are based on the PatternLiving Ranking System and do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.

Learn More

3. PRO-15 Probiotic

by Hyperbiotics

Ranked #3
PRO-15 Probiotic

Total Ranking

644 votes

8.7/10

B+

Overall Grade
  • INGREDIENT QUALITY
    8.7 AVG.
     8.7/10
  • POTENCY & ESTIMATED EFFICACY
    8.4 AVG.
     8.4/10
  • Value
    9.6 AVG.
     9.6/10
  • Return Policy
    9.6 AVG.
     9.6/10
  • CUSTOMER SATISFACTION
    9.5 AVG.
     9.5/10

PROS

  • 15 Strains
  • Survivability
  • Delayed-Release
  • Naturally Sourced
  • Vegetarian

CONS

  • Only 5 Billion CFUs
  • Hard to Swallow
  • Some Stomach Issues
  • Only 30-Day Return Policy
The Bottom Line

Hyperbiotics’ PRO-15 Probiotic features 15 strains, all of which are naturally sourced and already present in the human body. These non-GMO probiotics are vegetarian-friendly and are free of dairy, gluten, artificial additives, or preservatives.

These delayed-release capsules, which release over an 8-10 hour period, claim to have a 15x more survivability rate and do not require refrigeration. 

These probiotics, however, have a lower amount of CFUs compared to the others on our list coming in at 5 billion CFUs. While you only need to take one capsule a day, some reviewers state that the capsule is a bit harder to swallow. Additionally, despite claims of being for those with sensitive stomachs, some reviewers stated that they experience some stomach discomfort, including bloating.

*Results are based on the PatternLiving Ranking System and do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.

Learn More

4. Probiotic-10

by NOW

Ranked #4
Probiotic-10

Total Ranking

497 votes

8.1/10

B-

Overall Grade
  • INGREDIENT QUALITY
    7.9 AVG.
     7.9/10
  • POTENCY & ESTIMATED EFFICACY
    8.2 AVG.
     8.2/10
  • Value
    7.8 AVG.
     7.8/10
  • Return Policy
    7.8 AVG.
     7.8/10
  • CUSTOMER SATISFACTION
    8.1 AVG.
     8.1/10

PROS

  • 25 Billion CFUs
  • 10 Strains
  • Vegan & Vegetarian-Friendly

CONS

  • Not Delayed-Release
  • Must Be Refrigerated
  • Delayed Results
  • Non-Returnable
The Bottom Line

Free of soy, dairy, and gluten, these probiotics from NOW are a popular choice for those with dietary restrictions. They feature 25 billion CFUs through the Best By Date and contain 10 strains of probiotics.

Unfortunately, this is about where the pros end. These probiotics lack the delayed-release feature we love about the other options listed. They also need to be refrigerated to maintain survivability. Therefore, if ordering online, the microorganisms may not survive through shipping especially in the warmer months. This can also affect results.

At this time, NOW does not accept any returns.

*Results are based on the PatternLiving Ranking System and do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.

Learn More

5. Advanced Strength Probiotic

by BioSchwartz

Ranked #5
Advanced Strength Probiotic

Total Ranking

247 votes

7.9/10

C+

Overall Grade
  • INGREDIENT QUALITY
    8.2 AVG.
     8.2/10
  • POTENCY & ESTIMATED EFFICACY
    8.4 AVG.
     8.4/10
  • Value
    7.1 AVG.
     7.1/10
  • Return Policy
    6.8 AVG.
     6.8/10
  • CUSTOMER SATISFACTION
    7.9 AVG.
     7.9/10

PROS

  • 40 Billion CFUs
  • Shelf Life Potency Guaranteed
  • Naturally Sourced
  • Delayed-Release

CONS

  • Fewer Strains
  • Some Stomach Distress
  • Only 30-Day Return Policy
The Bottom Line

Featuring 40 billion CFUs, this probiotic from BioSchwartz guarantees shelf life potency until the expiration date and requires zero refrigeration. They are non-GMO, are 100% allergen-free, and contain no artificial additives. The delayed-release technology also ensures potency for maximum benefits.

Unlike our other options mentioned above, this probiotic contains the fewest amount of strains. Additionally, reviewers with sensitive stomachs have stated they have experienced some discomfort, including bloating and gas. 

*Results are based on the PatternLiving Ranking System and do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.

Learn More

Final Thoughts

The Bottom Line

When it comes to choosing a supplement for gut health, it is essential to choose a product that is made with high-quality ingredients, providing natural sources of CFUs, that are delivered in effective doses.

After searching the internet to find the best Probiotics products and evaluating them based on their customer service, ingredients, and pricing, we believe Pattern Wellness' Probiotic is the best on the market.

Pattern Wellness provides a 100% satisfaction guarantee & 30-day money-back guarantee on all orders!

Exclusive Offer Ongoing - 10% OFF
Exclusive Offer Ongoing - 10% OFF

Take advantage of this Offer while supplies last - Use code below:

CODE: BLOG10
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This special offer ends: Tuesday, January 28, 2025

Sources

  1. Kim, Seon-Kyun, et al. “Role of Probiotics in Human Gut Microbiome-Associated Diseases.” Journal of Microbiology and Biotechnology, vol. 29, no. 9, 2019, pp. 1335–1340., doi:10.4014/jmb.1906.06064. 
  2. Singh, Varun Pratap et al. “Role of probiotics in health and disease: a review.” JPMA. The Journal of the Pakistan Medical Association vol. 63,2 (2013): 253-7.
  3. Zhang, Yu-Jie et al. “Impacts of gut bacteria on human health and diseases.” International journal of molecular sciences vol. 16,4 7493-519. 2 Apr. 2015, doi:10.3390/ijms16047493
  4. Wieërs, Grégoire et al. “How Probiotics Affect the Microbiota.” Frontiers in cellular and infection microbiology vol. 9 454. 15 Jan. 2020, doi:10.3389/fcimb.2019.00454
  5. Zhang, Chenhong, et al. “Ecological Robustness of the Gut Microbiota in Response to Ingestion of Transient Food-Borne Microbes.” The ISME Journal, vol. 10, no. 9, 2016, pp. 2235–2245., doi:10.1038/ismej.2016.13. 
  6.  Kligler, Benjamin, and Andreas Cohrssen. “Probiotics.” American family physician vol. 78,9 (2008): 1073-8.
  7. Chang, Hung-Yang, et al. “Multiple Strains Probiotics Appear to Be the Most Effective Probiotics in the Prevention of Necrotizing Enterocolitis and Mortality: An Updated Meta-Analysis.” PLOS ONE, vol. 12, no. 2, 2017, doi:10.1371/journal.pone.0171579.  
  8. Fijan, Sabina. “Microorganisms with claimed probiotic properties: an overview of recent literature.” International journal of environmental research and public health vol. 11,5 4745-67. 5 May. 2014, doi:10.3390/ijerph110504745
  9. Mörkl, Sabrina et al. “Probiotics and the Microbiota-Gut-Brain Axis: Focus on Psychiatry.” Current nutrition reports vol. 9,3 (2020): 171-182. doi:10.1007/s13668-020-00313-5
  10. “Dietary Supplement Label Database (DSLD).” NIH Office of Dietary Supplements, U.S. Department of Health and Human Services, ods.od.nih.gov/Research/Dietary_Supplement_Label_Database.aspx. 
  11. Karczewski J, Troost FJ, Konings I, Dekker J, Kleerebezem M, Brummer RJ, Wells JM. Regulation of human epithelial tight junction proteins by Lactobacillus Plantarum in vivo and protective effects on the epithelial barrier. Am J Physiol Gastrointest Liver Physiol. 2010 Jun;298(6): G851-9. DOI: 10.1152/ajpgi.00327.2009. Epub 2010 Mar 11. PMID: 20224007.
  12. Wang Z, Xiao G, Yao Y, Guo S, Lu K, Sheng Z. The role of bifidobacteria in gut barrier function after thermal injury in rats. J Trauma. 2006 Sep;61(3):650-7. DOI: 10.1097/01.ta.0000196574.70614.27. PMID: 16967002.
  13. Markowiak, P., & Śliżewska, K. (2017). Effects of Probiotics, Prebiotics, and Synbiotics on Human Health. Nutrients, 9(9), 1021. https://doi.org/10.3390/nu9091021 
  14. Liu T, Cephas KD, Holscher HD, Kerr KR, Mangian HF, Tappenden KA, Swanson KS. Nondigestible Fructans alter gastrointestinal barrier function, gene expression, histomorphology, and the microbiota profiles of Diet-Induced Obese C57BL / 6J Mice. J Nutr 2016; 146:949-56 
  15. Olano-Martin, E., Gibson, G. R., & Rastell, R. A. (2002). Comparison of the in vitro bifidogenic properties of pectins and pectic-oligosaccharides. Journal of applied microbiology, 93(3), 505–511. https://doi.org/10.1046/j.1365-2672.2002.01719.x
  16. Jiang, T., Gao, X., Wu, C., Tian, F., Lei, Q., Bi, J., Xie, B., Wang, H. Y., Chen, S., & Wang, X. (2016). Apple-Derived Pectin Modulates Gut Microbiota, Improves Gut Barrier Function, and Attenuates Metabolic Endotoxemia in Rats with Diet-Induced Obesity. Nutrients, 8(3), 126. https://doi.org/10.3390/nu8030126
  17. Majewski M. (2014). Allium sativum: facts and myths regarding human health. Roczniki Panstwowego Zakladu Higieny, 65(1), 1–8. 
  18. Ankri, S., & Mirelman, D. (1999). Antimicrobial properties of allicin from garlic. Microbes and infection, 1(2), 125–129. https://doi.org/10.1016/s1286-4579(99)80003-3   

Rachel

Written by Rachel

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