Top 5 Leaky Gut Supplements of 2025 – Don’t Buy Until You Read This!

Top 5 Leaky Gut Supplements of 2025 – Don’t Buy Until You Read This!

By: Rachel

Your digestive system, while responsible for processing food, is also at the epicenter of the general well-being of your body. Believe it or not, your mental, emotional, and physical health all rely on your digestive system to break food down into nutrients for energy.[14,15]

However, what happens when your digestive tract can’t effectively transport and break down these food particles? When your organs don’t receive the nutrients they depend on to function, you’ll start to feel negative effects like fatigue, headaches, and even food sensitivity. This is called “leaky gut syndrome” and it’s much more common than you might think.[16]

What is Leaky Gut Syndrome?

Your digestive tract contains six important organs that break down food, absorb nutrients, and protect your body from toxins by maintaining a tight barrier in the intestinal wall. Leaky gut happens when the walls of your digestive tract become loose and inflamed, allowing harmful substances to leak through the digestive wall and into your bloodstream. 

Bile, bacteria, and other harmful substances that may flow into the bloodstream of someone suffering from a leaky gut can cause many problems including[1,5]

Allergies

Digestive Issues

Fatigue

Headaches

Food Sensitivity

Weight Fluctuation

Mood Swings

Skin Conditions

While some people are more prone to leaky gut syndrome than others, there are common risk factors that can wear down the walls of your digestive tract.

Common Causes of Leaky Gut

Excess Sugar

Poor Diet

Excessive Alcohol Consumption

Stress

Anti-inflammatory Drugs

While it can be pretty easy to irritate the walls of your digestive tract, there are several precautions you can take to keep your gut healthy and your intestinal walls functioning as they should. These include eating healthy fats, managing stress levels, and most importantly, taking a daily gut support supplement.

A quality gut support supplement can help provide digestive and immune system support, promote healthy gut bacteria, and much more. 

Unfortunately, not all gut support supplements are made the same. And with so many options on the market, it's tough to know what direction to take when looking for a high-quality solution. So, we did the hard work for you by revealing what to look for and what to avoid when shopping for the best leaky gut supplements to help with leaky gut syndrome.

We even researched hundreds of gut support supplements on the market to give you the 5 very best leaky gut supplements on the market today.

Top Ingredients to Help Leaky Gut Syndrome

Taking all of the healthful attributes listed above into consideration, we've boiled down a list of four key characteristics you should always look for when treating your gut health. Try to seek out all of these qualities:

Probiotics

Probiotics are live “good” bacteria that provide numerous health benefits.[6] There are two probiotics in particular that are worth noting:

Lactobacillus is a type of probiotic enzyme that has been shown to regulate the epithelial barriers in your body.[2] One very important epithelial barrier is the one that lines the digestive tract. By keeping this intact, you’ll have much lower chances of developing leaky gut syndrome.

Another probiotic strain, Bifidobacteria is amazing for colon health—especially for maintaining the colonic lining and preventing colitis.[3] On top of that, it helps to protect the intestinal barrier, likely providing therapeutic benefits for those who suffer from a leaky gut.

Prebiotics

Prebiotics are a form of dietary fiber. They feed the “good” bacteria in your gut and ultimately support a healthier digestive system.[6]

Look for a prebiotic blend that includes Organic Inulin, FOS, and Organic Apple Pectin. Inulin and FOS are longer chain and shorter chain fibers that help the good gut bacteria stay fed and flourish, while Apple Pectin helps inhibit the growth of harmful bacteria and provides extra fiber to assist with digestive health.[7,8,9]  

Abiotic™ Blend

An Abiotic Blend aids in the digestion of macronutrients. This blend includes Allicin (from organic garlic), Monolaurin (from Palm kernels), and NAC. Allicin specifically can provide a gut boost and detox to revive uncomfortable stomachs and balance healthy gut bacteria.[10,11]

High CFU Count

Since our microbiome is composed of about 100 trillion good and bad bacteria, a high number of Colony Forming Units (CFUs) will have a greater impact on the growth of beneficial bacteria within our gut.[4] It's essential to choose a probiotic that specifies CFU versus "active cultures" or "live cultures." 

While the potency and variety of strains are crucial when looking for a high-quality leaky gut supplement, it's equally important to know what to avoid when looking for an effective gut support supplement.

The following 3 tips should help you sidestep those not worth your time:

What Factors to Avoid

Absence of Clinical Studies

A high-quality gut support supplement will clearly identify its specific probiotic strains on the label. Indicated by a combination of letters and numbers following the strain's name (eg. L. gasseri L22G), these 'substrains,' tell you that they are backed by one or more clinical studies.

Unfortunately, many supplements on the market are made with generic (and cheaper) strains, so it's always a good idea to check the label to ensure specific substrains are there.

Unnecessary Additives

A leaky gut supplement shouldn’t contain anything that doesn’t provide you with healthful benefits. Avoid gut support supplements that contain any extra ingredients. You never know how your body might respond to unnecessary additives. This is especially true in terms of gluten and those who experience gluten sensitivity. Gluten has been shown to activate zonulin, which then leads to increased intestinal permeability.[12,13] 

Instead, look for a leaky gut supplement that is gluten-free and contains only naturally sourced, certified vegan, non-GMO probiotic strains.

Limited Strains

Probiotic strains serve different purposes in the body, so it's important to choose a gut support supplement that features a variety of robust strains. 

We recommend looking for a gut support supplement with a handful of unique strains for a more comprehensive approach to healing your digestive lining for improved overall health and immune function.

Top 5 Leaky Gut Supplements

Based on our own extensive research, the metrics provided by our Pattern Living Ranking System, and consideration of thousands of reviews by Shoppers just like you, we've compiled a list of what we've found to be the top five products in this category, on the market today.

1. Gut Support

by Pattern Wellness

Ranked #1
Gut Support

Total Ranking

1223 votes

9.7/10

A+

Overall Grade
  • INGREDIENT QUALITY
    9.7 AVG.
     9.7/10
  • POTENCY & ESTIMATED EFFICACY
    9.7 AVG.
     9.7/10
  • Value
    9.6 AVG.
     9.6/10
  • Return Policy
    9.6 AVG.
     9.6/10
  • CUSTOMER SATISFACTION
    9.5 AVG.
     9.5/10

PROS

  • Supports Healthy Gut Function
  • Promotes Healthy Gut Bacteria
  • Contains Prebiotics, Probiotics, & Abiotic™ Blend
  • No Fillers or Binders
  • Certified Vegan & Non-GMO
  • Gluten, Dairy, & Soy-Free
  • Excellent US-based customer service

CONS

  • Only Available Online
The Bottom Line

Pattern Wellness’ Gut Support offers an incredible value featuring a blend of Probiotics and prebiotics, and an Abiotic blend, which are packed with many healthful benefits including digestive and immune support, promoting healthy gut bacteria, and reduces the effects of seasonal allergies.*

This certified hormone-free, non-GMO supplement is free of gluten, dairy, and soy, making it a formula you can trust. 

Their return policy includes a 90-day, risk-free, money-back guarantee—proving the company stands behind its products.

*Results are based on the PatternLiving Ranking System and do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.

Learn About Our Top Pick

2. Probiotics 60 Billion CFU

by Physician's CHOICE

Ranked #2
Probiotics 60 Billion CFU

Total Ranking

742 votes

9.1/10

A-

Overall Grade
  • INGREDIENT QUALITY
    9.2 AVG.
     9.2/10
  • POTENCY & ESTIMATED EFFICACY
    9.4 AVG.
     9.4/10
  • Value
    8.9 AVG.
     8.9/10
  • Return Policy
    9 AVG.
     9/10
  • CUSTOMER SATISFACTION
    9.5 AVG.
     9.5/10

PROS

  • 60 Billion CFUs
  • Contains Prebiotics & 10 Probiotic Strains
  • Formulated to Protect Digestive Barrier
  • Non-GMO & Gluten-Free

CONS

  • Missing Additional Beneficial Ingredients
  • Stability Varies
  • Non-returnable After 60 Days
The Bottom Line

The Physician’s Choice Probiotic is an excellent choice due to the amount of CFUs, prebiotics, probiotic strains, and the natural, vegan nature of its contents. It contains the essential bacteria strain to support overall digestive health and goes for a relatively affordable price.

On the other hand, we decided to put this one in second place due to its limited return policy. Also, while many customers report the supplement to work very well, others have found its shelf life isn’t as long as advertised.

*Results are based on the PatternLiving Ranking System and do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.

Learn More

3. Advanced Digestive Enzymes

by Zenwise Health

Ranked #3
Advanced Digestive Enzymes

Total Ranking

644 votes

8.7/10

B+

Overall Grade
  • INGREDIENT QUALITY
    8.7 AVG.
     8.7/10
  • POTENCY & ESTIMATED EFFICACY
    8.4 AVG.
     8.4/10
  • Value
    9.6 AVG.
     9.6/10
  • Return Policy
    9.6 AVG.
     9.6/10
  • CUSTOMER SATISFACTION
    9.5 AVG.
     9.5/10

PROS

  • Contains Prebiotics + Probiotics
  • Contains Apple Pectin
  • Allergen-Free

CONS

  • Missing Allicin & Other Beneficial Ingredients
  • Low CFU
  • Some Stomach Distress
  • Non-Returnable
The Bottom Line

Featuring premium ingredients, this enzyme blend made the list due to its impressive ingredient lineup, which includes a prebiotic blend, probiotic blend, and a botanical blend that includes Apple Pectin. While their ingredients are beneficial in terms of gut health, we were missing a few like Allicin and Palm kernels. They are non-GMO, 100% allergen-free, and contain no artificial additives.

Unlike our other options mentioned above, this gut support blend contains a low dosage of probiotics, coming in at only 1 billion CFUs. Additionally, reviewers with sensitive stomachs have stated they have experienced some discomfort. Despite that, majority of shoppers have said this Digestive Enzyme blend has been fantastic for digestion support.

*Results are based on the PatternLiving Ranking System and do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.

Learn More

4. Probiotic-10

by NOW

Ranked #4
Probiotic-10

Total Ranking

497 votes

8.1/10

B-

Overall Grade
  • INGREDIENT QUALITY
    7.9 AVG.
     7.9/10
  • POTENCY & ESTIMATED EFFICACY
    8.2 AVG.
     8.2/10
  • Value
    7.8 AVG.
     7.8/10
  • Return Policy
    7.8 AVG.
     7.8/10
  • CUSTOMER SATISFACTION
    8.1 AVG.
     8.1/10

PROS

  • 25 Billion CFUs
  • 10 Probiotic Strains
  • Dairy- & Gluten-Free

CONS

  • Only Contains Probiotics
  • Non-Returnable
The Bottom Line

Free of soy, dairy, and gluten, these probiotics from NOW are a popular choice for those with dietary restrictions. They feature 25 billion CFUs through the Best By Date and contain 10 strains of probiotics including those that benefit your digestive lining.

Unfortunately, this is about where the pros end. While this is a great gut support supplement that is said to help support healthy intestinal flora, it is simply a probiotic. We have found that in instances concerning leaky gut, a blend of prebiotics, probiotics, and additional beneficial ingredients reaped better results. 

At this time, NOW does not accept any returns.

*Results are based on the PatternLiving Ranking System and do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.

Learn More

5. Probiotics 100 Billion CFU

by Carlyle

Ranked #5
Probiotics 100 Billion CFU

Total Ranking

247 votes

7.9/10

C+

Overall Grade
  • INGREDIENT QUALITY
    8.2 AVG.
     8.2/10
  • POTENCY & ESTIMATED EFFICACY
    8.4 AVG.
     8.4/10
  • Value
    7.1 AVG.
     7.1/10
  • Return Policy
    6.8 AVG.
     6.8/10
  • CUSTOMER SATISFACTION
    7.9 AVG.
     7.9/10

PROS

  • 120 Billion CFUs
  • Contains Prebiotics
  • 14 Probiotic Strains
  • Gluten-Free

CONS

  • Made Outside of USA
  • Delayed Results
  • Not Vegan-Friendly
The Bottom Line

Carlyle’s probiotic is another solid choice if you’re looking to manage or prevent leaky gut syndrome. The family-owned supplement producer formulated this probiotic to contain 14 unique strains of bacteria and 120 billion CFUs. While it’s important to have at least 40 billion CFUs, anything more than 100 billion doesn’t make much of a difference.

The supplement is packaged and lab-tested in the U.S. However, the manufacturer doesn’t state that it’s made in the USA. Supplements made outside of the U.S. can also be of good quality, but often they might go through different manufacturing processes that use materials that aren’t allowed under U.S. regulations. Despite this, they seem to work well for customers.

*Results are based on the PatternLiving Ranking System and do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.

Learn More

Final Thoughts

The Bottom Line

When it comes to choosing the right leaky gut supplement, it is essential to choose a product that is made with high-quality ingredients delivered in optimal doses from a brand you can trust.  

After searching the internet to find the best leaky gut supplement and evaluating them based on their customer service, ingredients and pricing, we believe Pattern Wellness’ Gut Support is the best on the market.

Pattern Wellness provides a 100% satisfaction guarantee or your money back.

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Sources

  1. Rao RK, Samak G. Protection and Restitution of Gut Barrier by Probiotics: Nutritional and Clinical Implications. Curr Nutr Food Sci. 2013;9(2):99-107. doi:10.2174/1573401311309020004
  2. Karczewski J, Troost FJ, Konings I, Dekker J, Kleerebezem M, Brummer RJ, Wells JM. Regulation of human epithelial tight junction proteins by Lactobacillus Plantarum in vivo and protective effects on the epithelial barrier. Am J Physiol Gastrointest Liver Physiol. 2010 Jun;298(6): G851-9. DOI: 10.1152/ajpgi.00327.2009. Epub 2010 Mar 11. PMID: 20224007.
  3. Wang Z, Xiao G, Yao Y, Guo S, Lu K, Sheng Z. The role of bifidobacteria in gut barrier function after thermal injury in rats. J Trauma. 2006 Sep;61(3):650-7. DOI: 10.1097/01.ta.0000196574.70614.27. PMID: 16967002.
  4. Singh, Varun Pratap et al. “Role of probiotics in health and disease: a review.” JPMA. The Journal of the Pakistan Medical Association vol. 63,2 (2013): 253-7.
  5. Odenwald, M. A., & Turner, J. R. (2013). Intestinal permeability defects: is it time to treat?. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 11(9), 1075–1083. https://doi.org/10.1016/j.cgh.2013.07.001
  6. Markowiak, P., & Śliżewska, K. (2017). Effects of Probiotics, Prebiotics, and Synbiotics on Human Health. Nutrients, 9(9), 1021. https://doi.org/10.3390/nu9091021 
  7. Liu T, Cephas KD, Holscher HD, Kerr KR, Mangian HF, Tappenden KA, Swanson KS. Nondigestible Fructans alter gastrointestinal barrier function, gene expression, histomorphology, and the microbiota profiles of Diet-Induced Obese C57BL / 6J Mice. J Nutr 2016; 146:949-56 
  8. Olano-Martin, E., Gibson, G. R., & Rastell, R. A. (2002). Comparison of the in vitro bifidogenic properties of pectins and pectic-oligosaccharides. Journal of applied microbiology, 93(3), 505–511. https://doi.org/10.1046/j.1365-2672.2002.01719.x
  9. Jiang, T., Gao, X., Wu, C., Tian, F., Lei, Q., Bi, J., Xie, B., Wang, H. Y., Chen, S., & Wang, X. (2016). Apple-Derived Pectin Modulates Gut Microbiota, Improves Gut Barrier Function, and Attenuates Metabolic Endotoxemia in Rats with Diet-Induced Obesity. Nutrients, 8(3), 126. https://doi.org/10.3390/nu8030126
  10. Majewski M. (2014). Allium sativum: facts and myths regarding human health. Roczniki Panstwowego Zakladu Higieny, 65(1), 1–8. 
  11. Ankri, S., & Mirelman, D. (1999). Antimicrobial properties of allicin from garlic. Microbes and infection, 1(2), 125–129. https://doi.org/10.1016/s1286-4579(99)80003-3   
  12. Lammers, K. M., Lu, R., Brownley, J., Lu, B., Gerard, C., Thomas, K., Rallabhandi, P., Shea-Donohue, T., Tamiz, A., Alkan, S., Netzel-Arnett, S., Antalis, T., Vogel, S. N., & Fasano, A. (2008). Gliadin induces an increase in intestinal permeability and zonulin release by binding to the chemokine receptor CXCR3. Gastroenterology, 135(1), 194–204.e3. https://doi.org/10.1053/j.gastro.2008.03.023 
  13. Drago, S., El Asmar, R., Di Pierro, M., Grazia Clemente, M., Tripathi, A., Sapone, A., Thakar, M., Iacono, G., Carroccio, A., D'Agate, C., Not, T., Zampini, L., Catassi, C., & Fasano, A. (2006). Gliadin, zonulin and gut permeability: Effects on celiac and non-celiac intestinal mucosa and intestinal cell lines. Scandinavian journal of gastroenterology, 41(4), 408–419. https://doi.org/10.1080/00365520500235334 
  14. Clapp, M., Aurora, N., Herrera, L., Bhatia, M., Wilen, E., & Wakefield, S. (2017). Gut microbiota's effect on mental health: The gut-brain axis. Clinics and practice, 7(4), 987. https://doi.org/10.4081/cp.2017.987 
  15. Food Forum; Food and Nutrition Board; Institute of Medicine. Relationships Among the Brain, the Digestive System, and Eating Behavior: Workshop Summary. Washington (DC): National Academies Press (US); 2015 Feb 27. 2, Interaction Between the Brain and the Digestive System. Available from: https://www.ncbi.nlm.nih.gov/books/NBK279994/ 
  16. Arrieta, M. C., Bistritz, L., & Meddings, J. B. (2006). Alterations in intestinal permeability. Gut, 55(10), 1512–1520. https://doi.org/10.1136/gut.2005.085373 

 

Rachel

Written by Rachel

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